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Sympathetic activity and arrhythmias in long QT: a missing link?
Presentation title:
Sympathetic activity and arrhythmias in long QT: a missing link?
Author(s):
Wilde A.A.M. (Amsterdam, NL)
Date:
30 August 2004
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Sympathetic activity and Arrhythmias in long QT syndrome A missing link? ESC, Munchen 2004
Long QT syndrome Subdivision of genotyped patients
Congenital LQTS symptomatology
LQT1 pre-exercise QTc = 440 ms
LQT1 during exercise QTc = 500 ms
LQTS1 model (perfused LV wedge) Shimizu & Antzelevitch, Circulation 1998;98:2314-22
LQTS1 model (perfused LV wedge) Shimizu & Antzelevitch, Circulation 1998;98:2314-22
Long QT syndrome, type 1 & 2 Mechanisms of reduced current
KCNQ1, ß-adrenoceptor stimulation
KCNQ1, ß-adrenoceptor stimulation
KCNQ1, ß-adrenoceptor stimulation
Arrhythmogenesis in LQTS type 1
Arrhythmogenesis in LQTS type 1
Acknowledgements
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