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Antiplatelet treatment
Presentation title:
Antiplatelet treatment
Author(s):
R. Califf (Durham, US)
Date:
01 September 2003
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Antiplatelet Therapy in Non-ST Elevation ACS
Conflicts
Platelets and Cardiovascular Disease: Importance of Micro and Macro Coronary Embolization
Acute Coronary Disease: Contributing Factors
Platelets and Cardiovascular Disease: Relationship between Platelets and Coagulation
Spectrum of Acute Coronary Syndromes
Duke ACS Algorithm
Hospital Care Anti-Thrombotic Therapy
Hospital Care Clopidogrel Therapy
Hospital Care Platelet GP IIb/IIIa Inhibitors (1)
Discharge/Post-Discharge Medications
Antiplatelet Tx and ACS—What we Don’t Know
Aspirin in Unstable Angina—Aspirin Beneficial!
Relationship between Aspirin Dosing and Outcome in Non-ST Elevation ACS—Higher Dose looks better for ischemic events!—but not definitive
Aspirin Responsiveness and Clinical Outcome
Should we give aspirin?
CURE Trial: Study Design
Clopidogrel and ASA in ACS: CURE Results
Early Benefit of Dual Oral Antiplatelet Therapy in ACS: Death/MI/Ischemia < 24 Hrs in CURE
Clopidogrel and ASA in ACS: CABG-Related Bleeding in CURE
Consistent Benefit of Clopidogrel Pretreatment
Timing of Loading Dose—Earlier is Better
Clopidogrel Pretreatment and GP IIb/IIIa Antagonists--? synergistic
NEW FINDING ON CLOPIDOGREL RESISTANCE
Should we give clopidogrel?
Major Trials of IV GP IIb/IIIa Receptor Antagonists: Completed, Placebo-Controlled RCTs
GP IIb/IIIa Inhibition for Non-ST-Elevation ACS
Platelet GP IIb/IIIa Inhibitors in NSTE ACS: Subgroups
“Protein-Targeted” Treatment Strategies in ACS: Benefit of GPIIb/IIIa Inhibitor by Troponin Status
Mortality By Early GP IIb-IIIa Inhibitor Use Observational Data from 400 US Hospitals
Mortality by Early GP IIb-IIIa Inhibitor (w/in 24 Hrs) RCT Trials vs NRMI vs CRUSADE Study—All observational data
Should we use IV Gp IIb/IIIa inhibitor?
Gap between Leading and Lagging Hospital Quartiles: Discharge Care
Relationship between Overall Composite Quality and In-hospital Mortality
Antiplatelet Therapy in Non-ST Elevation ACS Conclusions
The Cycle of Clinical Therapeutics—New Model
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