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HRT - what is it?

Presentation title: HRT - what is it?

Author(s): Gambacciani M.

Date: 12 May 2006

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HRT what is it?	Guidelines for Hormone Treatment of Women in the Menopausal Transition and beyond	DEFINING TERMS USED TO DESCRIBE MENOPAUSAL HORMONE TREATMENT (MHT)
HRT vs HTwhy we have to keep the “R”	Estrogen Loss and Hormone ReplacementManifestations of Health Risks Over Time	Pre WHI era Benefits and risks of HRT
“The extent to which beliefs are based on evidence is very much less than what believers suppose.” Bertrand Russell	EVIDENCES IN MEDICINE	HRT and cancer
Established and probable risk factors for breast cancer		Absolute Risk of Breast Cancer
		AMERICAN CANCER SOCIETY, 1998
OC lung cancer protection supported	Women Health Initiative Trial	Risk of Breast Cancer in the WHI, after 5.2 years of CEE/MPA administration
Effects of CEE on Breast Cancer and Mammography Screening in Postmenopausal Women With Hysterectomy	Unopposed Estrogen Therapy and the Risk of Invasive Breast Cancer the Nurses' Health Study, a prospective cohort study, 28 835 women	Annual risks & benefits after 7 years of E-only HT (Adapted from US WHI Study, 2004)
Low-dosage micronized 17 beta-estradiol + calcium prevent bone loss in postmenopausal women.	Number of Hot Flushes	Estrogen deprivation and Symptomatic PMW
Non-hormonal menopause therapies 'not as effective as estrogen'	Emerging Directions in Hormone Replacement Therapy	The Replacement Concept
Age –specific HRT use	Age –specific Hormone InitiationNHS 1976-2000	The reasons to take HRT
Two to three years of HRT in healthy women have long-term preventive effects on bone mass and osteoporotic fractures	The OP epidemicFx incidence and perimenopausal HRT	ULTIMATE HRT EFFECTS
ULTIMATE HRT EFFECTS	Mortality Associated with HRT in Younger and Older WomenA Meta-analysis	First-year CHD and vascular events with HRT use in 2 trials of younger PMW andexpected annual rates in women in the USA and Europe
	Aging and Methylation of the ER
		HRT2006 Conclusions
HRT SELECTION CRITERIAthe need for different choices and combinations		Guideline and Recommendations
Risk of Incident AD: The Effect of HRT		HRT after menopause
Baseline characteristics: observational studies versus WHI	POPULATION CHARACTERISTICS	CLIMACTERIC HEALTH CARE
A final thought from a pioneer :	IMS Guidelines for Women during the Climacteric
	WHI POPULATION CHARACTERISTICS	IMS Guidelines for Women during the Climacteric
IMS Guidelines for Women during the Climacteric	IMS Guidelines for Women during the Climacteric	Effect of HRT-ERT on CHD in PMW Timing of initiation, Data From WHI
First-Year CHD and Vascular Events With HT Use in 2 Trials of Younger Postmenopausal Women and Expected Annual Rates in Women in the United States and Europe	Estrogen plus progestin and risk of venous thrombosis: the WHI clinical trial	IMS Guidelines for Women during the Climacteric
IMS Guidelines for Women during the Climacteric	IMS Guidelines for Women during the Climacteric	IMS Guidelines for Women during the Climacteric
IMS Guidelines for Women during the Climacteric	IMS Guidelines for Women during the Climacteric	IMS Guidelines for Women during the Climacteric
IMS Guidelines for Women during the Climacteric	Risk of breast cancer in the WHI	IMS Guidelines for Women during the Climacteric
IMS Guidelines for Women during the Climacteric	IMS Guidelines for Women during the Climacteric	IMS Guidelines for Women during the Climacteric
IMS Guidelines for Women during the Climacteric		IMS Guidelines for Women during the Climacteric
IMS Guidelines for Women during the Climacteric	IMS Guidelines for Women during the Climacteric
IMS Guidelines for Women during the Climacteric		physical changes during the climacteric
linee guida essenziali per il trattamento ormonale sostitutivo (HRT) in menopausa	Passive and active smoking and breast cancer risk in Canada, 1994-97. The Canadian Cancer Registries Epidemiology Research Group

ERT and the reduction of fracture		WHI Results at the 5.2 years Absolute Risk or Benefit of CEE/MPA
	WHI Results
Review of Observational Studies Published From 1975-2000

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