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Inflammation and chronic heart failure: does it really matter?

Presentation title: Inflammation and chronic heart failure: does it really matter?

Author(s): V. Conraads

Date: 08 April 2005

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Inflammation and Chronic Heart Failure:Does it really matter?		Pro-inflammatory cytokines
	Pro-inflammatory cytokines: Observational studies	Deswal A, et al. Circulation 2001;103:2055. Cytokines and Cytokine Receptors in Advanced Heart Failure An Analysis of the Cytokine Database from the Vesnarinone Trial
Pro-inflammatory Cytokines in Chronic Heart Failure:Causal orEpiphenomenon?	Causal versus Epiphenomenon	Causal versus Epiphenomenon
	Causal versus Epiphenomenon	Prognostic relevance
Causal versus Epiphenomenon	Cytokines and Pathophysiological role	Cytokines and Pathophysiological role
Cytokines and Pathophysiological role	Cytokines and Pathophysiological role	Cytokines and Pathophysiological role

		Myocardium as a source
		Peripheral tissues as a source
	Endotoxin as a stimulus for immune activation: background
	Faecal Endotoxin Monocyte IC Cytokine Production	Causal versus Epiphenomenon
Anti-inflammatory therapy: targeted anti-TNF therapy		Anti-inflammatory therapy: Etanercept
	Anti-inflammatory therapy: Infliximab
TNFa	Restoring the balance	Immunemodulation
Sliwa K, et al. Circulation 2004;109:750Therapy of Ischemic Cardiomyopathy With the Immunomodulating Agent Pentoxifylline.	Immunemodulation
Gullestad L, et al. Circulation. 2001;103:220.Immunomodulating Therapy With Intravenous Immunoglobulin in Patients With Chronic Heart Failure.	Immunemodulation?Daily practice!ACE-inhibitors,sartans,beta-blockade,amiodaroneStatins,Exercise Training	Conraads VM, et al. Eur Heart J. 2003;24:2221 Association of lipoproteins with cytokines and cytokine receptors in heart failure patients. Differences between ischaemic versus idiopathic cardiomyopathy.
	Node K, et al. Circulation 2003;108:839 Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy.	Exercise training(in 5 minutes)

	Cytokines in Chronic Heart Failure, still hot!	Low cholesterol= statin-induced low cholesterol
Statin therapy in CHF1	Statin therapy in CHF2	Statin therapy in CHF3

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