European Society of Cardiology
Skip navigation links
About the ESC
Guidelines & Surveys
Welcome to the European Society of Cardiology. Our mission: to reduce the burden of cardiovascular disease in Europe

Keynote lecture

Frontiers in CardioVascular Biology 2012

Lessons in Science: competition in scientific research

Friday 30 March 2012
10:15-11:00 - Great Hall
View the scientific programme online (SPO)

Sir Professor Salvador Moncada (London, UK)

After qualification as a clinician in El Salvador, Salvador Moncada came to the UK as a research fellow to work with John Vane in 1971, and was one of the team responsible for the discovery that aspirin acts by blocking prostaglandin synthesis. After a brief return to Honduras he returned to Vane’s lab in 1974, where he discovered prostacyclin. In 1988 Moncada’s lab demonstrated that the second, more recently identified endothelium-derived relaxing factor, nitric oxide, was synthesised from arginine, enabling the rapid development of tools to manipulate NO production. These key contributions, and associated research, have made him one of the most highly cited scientists in the world.  He was elected a Fellow of the Royal Society in 1988, and knighted in 2010 for his services to science. His current research, based at UCL, remains highly innovatory and includes novel insights into how mitochondrial interactions with NO control cell responses to hypoxia, and how the cell cycle is controlled by glycolytic metabolism.