European Society of Cardiology
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Welcome to the European Society of Cardiology. Our mission: to reduce the burden of cardiovascular disease in Europe

Abstract sessions

Frontiers in CardioVascular Biology 2012

Oral abstract presentations

Featured Oral Presentations 
Number of abstracts with content related to the pre-arranged sessions of the Scientific Programme have been selected and will be presented in the sessions themselves.
Dedicated Oral Abstract Session 
Six selected abstracts will be orally presented during speacial oral abstract session on Saturday 31 March 2012 - 13:30-15:00 - Lecture Theatre 311. 

Young investigator competition session

Session dedicated to Young Investigators where six selected finalist will present their research. Panel of renowned expert judges evaluate their presentations for final award price. 

our Congratulations go to


Abstract 251 - Mitofusin 2 controls calcium transmission between the SR and mitochondria and regulates the bioenergetic feedback response in cardiac myocytes
M. Meiser - Medical student in her 4th year at the University of Saarland in Homburg, Germany. Since 2010 she works on her doctoral thesis focused on mitochondrial Ca2+ signalling.


Abstract 253 - Absence of microRNA-155 protects against adverse cardiac inflammation and hypertrophy during pressure overload and prevents heart failure
B Schroen - Molecular biologist at the Cardiovascular Research Institute Maastricht specialized in the role of non-coding RNAs in heart failure.
  Abstract 254 - Syndecan-4, a z-disc proteoglycan, regulates mechanical stress-induced, pro-hypertrophic NFAT signaling in cardiomyocytes through a direct interaction with calcineurin
IG Lunde - PhD student graduating in May 2012 at the Institute for Experimental
Medical Research and Center for Heart Failure Research, University of  Oslo and Oslo University Hospital, Oslo, Norway.
Her research focuses on molecular signalling pathways underlying development of cardiac hypertrophy and failure.

  Abstract 252 - B Stapel  -  Cardiac STAT3 deficiency is a pre-disposition for heart failure in response to beta-adrenergic stimulation 
  Abstract 255 - J Paavola -  PKD2 mutations lead to impaired calcium cycling in the heart and predispose to heart failure
  Abstract 256 - P RobinsonCardiomyopathy-causing mutations in cardiac thin filament regulatory proteins acutely affect Ca2+ buffering and Ca2+ dependant signalling in situ.

Poster sessions presentations and Awards

Presenters briefly discussed the content of their poster in front of an appreciative audience during official lunch and coffee breaks. Teams of expert judges reviewed all presentations and selected winners of the day.

our Congratulations go to

Friday 30 March 2012 

Winners - Best poster presentations:

P83 - G. Foldes - Transplantation of human embryonic stem cell-derived endothelial cells into rats: a new approach for vascular regeneration
  P199 - J Ritterhoff - S100A1 gene therapy protects cardiomyocytes against pro-arrhythmogenic Ca2+ waves and after-contractions

Judges Choice selected abstract presentations:
P63 - Adenosine A1-receptor agonism counteracts hypertrophy and fibrosis in response to alpha-adrenergic stimulation 
P91 - The beta-3 adrenoreceptor inhibits cardiac hypertrophy through nitric oxide synthase and activation of AMP-activated protein kinase  
P104 - Preferential re-entrant excitations for atrial fibrillation/flutter arising from the coronary sinus through the left atrial roof in rat hearts, a combined analysis by optical mapping and histology
P119 - Beta-2 adrenergic receptor signaling in adult rat ventricular myocytes at 4, 8 and 16 weeks after myocardial infarction
P128 - NADPH oxidase (NOX2) activation by hyperglycemia in cardiomyocytes is independent of glucose metabolism but requires SGLT-1 and a caveolae-associated signalosome
P140 - Deficiency in Tissue Kallikrein abolishes the cardio protective effects of CsA during post-conditioning in mice
P152 - Galectin-3 is a potential mediator of aldosterone effects in vascular remodeling
P163 - Angiopoietin-2: mediator of septic hypercirculation
P173 - Interleukin-33 induces urokinase-type plasminogen activator and plasminogen activator inhibitor type-1 in human endothelial cells in vitro
P202 - Increased right ventricular diastolic stiffness in idiopathic pulmonary arterial hypertension is associated with disease severity

Saturday 31 March 2012
Winners - Best poster presentations:

P311 - K. Hamesch - The CXCR4 antagonist POL5551 is equally effective as sirolimus in reducing neointima formation after arterial injury without impairing re-endothelialisation
  P429 - S. Prapa - Biomechanical perspectives of thoracic aortic aneurysm formation in patients with a bicuspid aortic valve: an integrated analysis

Judges Choice selected abstract presentations:
P284 - Pressure-controlled intermittent coronary sinus occlusion (PICSO) study on mechanical control of cardiac tissue morphogenesis
P299 - The Cdkn2a/2b tumour suppressor locus is a hot spot for genome instability in mouse cardiac progenitor cells
P325 - Anisotropic extracellular resistances influence action potential upstroke within subepicardial layers in the intact isolated rabbit heart.
P335 - Novel MLP-interacting proteins and their potential role in cardiomyopathy.
P361 - Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4.
P369 - Cleaved high molecular weight kininogen (HKa) prevents neointima formation following vascular injury.
P380 - Tbx1 is required in brain endothelial cells to establish vascular patterning.
P392 - High levels of OX40 and 4-1BB in CD4+CD28null T-cells identify a group of patients with coronary atherosclerosis that could benefit from targeted modulation of costimulatory pathways.
P401 - AMP-activated protein kinase activation is associated with an inhibition of fibrotic properties of cardiac fibroblasts.
P412 - Ibuprofen-eluting stents: a novel therapeutic approach in the prevention of in-stent stenosis.

Sunday 1 April 2012
Winners - Best poster presentations:

P477 - N. Smart - An essential role for thymosin beta 4 in regulating vascular smooth muscle cell development and adult vessel stability.
  P554 - PJM Wijnker - Impact of site specific phosphorylation of the protein kinase A sites Ser23 and Ser24 of cardiac troponin I on contractile function in human cardiomyocytes

Judges Choice selected abstract presentations:
P487 - Cardiomyocyte-specific overexpression of microRNA-30c leads to severe atrial and ventricular dilation
P500 - Fgf10 regulates fetal cardiac growth 
P520 - Resting cardiac sympathetic activity is required for the maintenance of cardiomyocyte trophism in the adulthood and is impaired during aging.
P537 - Characterisation of electrical activity in the infarct region of rat hearts using widefield epifluorescence and 2-photon excitation techniques
P564 - Levosimendan exhibits anti-inflammatory effects on human cardiac myocytes and endothelial cells in vitro
P584 - Smooth muscle cell-cytoskeleton dynamics in lipid-loaded human vascular smooth muscle cells is dependent on ROCK-signaling.
P611 - Imaging mass spectrometry for direct Heart tissue analysis :a new frontier for molecular histology.
P617 - The roles of nesprins in cardiac cell function
P630 - Repair of mutant pre-mRNA by spliceosome-mediated RNA trans-splicing in cardiac myocytes from Mybpc3-targeted knock-in mice
P642 - Identification of LOX-1 and Legumain as novel biomarkers in acute coronary syndromes using differential gene expression comparing coronary thrombi with peripheral blood

Other Poster Awards

  Investigative Pathology in Cardiovascular Diseases Award
Distributed by the Association for European Cardiovascular Pathology

P589 - PAJ Krijnen - Loss of DPP4 activity is related to a pro-thrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patients.

ESC WG on Cardiac Cellular Electrophysiology
Oral & Poster Awards

Oral Presentation Award:
458 - Cecilia Ferrantini - Action potential propagation in transverse-axial tubular system is impaired in heart failure

Poster Presentation Award:
P537 - Iffath Ayesha Ghouri - Characterisation of electrical activity in the infarct region of rat hearts using widefield epifluorescence and 2-photon excitation techniques


The Congress Programme Committee would like to thank all submitters and presenters for their contribution to the scientific programme - all Abstract Reviewers for their time to ensure that abstract programme represents new and original work of real scientific merit - and all onsite abstract Judges for their time and dedication.