Clinical Case Portal


Aortic sinus pseudoaneurysm complicating E. aerogenes late bioprosthetic endocarditis



Date of publication:

31 Oct 2008

Topics:

Diseases of the Aorta and Trauma to the Aorta and Heart
Infective Endocarditis
Valvular Heart Diseases

Authors:

Gabriel Retegui MD


Authors details:


Jesus Marin MD, Adrian Revello MD, Mariano R. Borrell MD, Begoña P. Cano MD, Francisco Florian MD, Rocío P.Yglesia MD.



Contact:

Hospital San Juan de Dios, Av. San Juan de Dios s/n, Bormujos (Seville), Spain

Abstract


A 77-year-old man presented eight months after bioprosthetic aortic valve implantation with progressive dyspnea and fever. E. aerogenes was isolated in culture bottles.


Introduction

Transesophageal echocardiographic revealed a pseudoaneurysm at the posterior-coronary sinus region and severe left ventricular dysfunction. About six months ago a previously TEE was considered normal and E. aerogenes was isolated in culture bottles. The patient refused surgery and was treated conservationally, being finally dead.

Case Report

Patient history prior to current observation :

A 77-year old man,  with a history of diabetes, arterial hypertension and implantation of a permanent DDD pacemaker for symptomatic AV block , was referred to Cardiac Surgery due to severe aortic stenosis and replacement with Carpentier nº21 bioprosthesis. A coronariography that proved to be normal was previously performed. During the next months the  patient experienced intermitent episodies with fever, loss of appetite and weakness.

Clinical findings on admission, evolution and outcome :

 
Two and half months later he presented to our emergency department with persistent fever and chills. The results of standard laboratory analyses, chest X-ray, 12-lead ECG and his physical examination were within normal limits. Enterobacter aerogenes was isolated in four sets of  blood culture bottles. Transesophageal echocardiography (ETE) showed no signs of prosthetic endocarditis. The patient was treated initially with vancomicine and gentamicine but developed  acute renal failure from nephrotoxicity. Then, he improved clinically with a course of intravenous cloxaciline and levofloxacin and was discharged from hospital. Four months later the patient´s family brought him back with intense dyspnea and fever. The valuation was completed carring out a new ETE that demonstrated a pseudoaneurysm at the posterior –coronary sinus region with holodiastolic high flow velocity inside (video 1,2,3,4) . The intimal flap was confined to only 1-cm segment of  aortic annulus. Normal values of prosthetic valve Doppler parameters were measured and no valve regurgitation or fistulization was evident. Severe impairment left ventricular function was revealed. The patient refused surgery and preferred home treatment and heart failure care. He died six months later.

Conclusion

Periannular extension from an infected prosthetic valve can lead to bacterial seeding and destruction of the arterial wall with formation of a pseudoaneurysm. This complication involved aortic valve endocarditis more commonly than mitral or tricuspid valve endocarditis. The natural history of these lesions is the rupture and the fistulization. Transesophageal echocardiography is an invaluable tool in diagnosis of the complicated valve endocarditis. Enterobacter species are important nosocomial pathogens responsible for various infections including rarely endocarditis. The mitral valve was most frequently involved and only a case of E. cloacae  endocarditis following mitral valve replacement with a porcine heterograft has been related. To our knowledge, there have no reports of  pseudoaneurysm at the coronary sinus complicating an E. aerogenes late phrosthetic endocarditis.

fig. 1 :
Posterior aortic sinus disecction

Posterior aortic sinus disecction

Legend : Play video
: Full Screen video
: Sound video

fig. 2 :
Pseudoaneurysm of the mitral-aortic intervalvular fibrosa

Pseudoaneurysm of the mitral-aortic intervalvular fibrosa

Legend : Play video
: Full Screen video
: Sound video

fig. 3 :
Color flow into the false lumen

Color flow into the false lumen

Legend : Play video
: Full Screen video
: Sound video

fig. 4 :
Aortic dissection with surgical thread inside

Aortic dissection with surgical thread inside

Legend : Play video
: Full Screen video
: Sound video
 
Highlight On
Explore the Box here