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Key library: Basic Science

Recommended publications selected for you by the EACPR Basic & Translational Research section

Effect of increased exercise in school children on physical fitness  and endothelial progenitor cells: a prospective randomized trial. 
Walther C, Gaede L, Adams V, Gelbrich G, Leichtle A, Erbs S, Sonnabend 
M, Fikenzer K, Körner A, Kiess W, Bruegel M, Thiery J, Schuler G.
Circulation 120:2251-2259 (2009)

Regular exercise training prevents aortic valve disease in low-density lipoprotein receptor deficient mice 
Matsumoto Y, Adams V, Jacob S, Mangner N, Schuler G, Linke A.
Circulation 121:759-767 (2010)Time dependent mobilization of circulating progenitor cells during strenuous exercise in healthy individuals.
Möbius-Winkler S, Hilberg T, Menzel K, Golla E, Burman A, Schuler G, Adams V. 
J Appl Pysiol 107:1943-50 (2009).Validity and reliability of omron pedometers at slow walking speeds
Jehn ML, Schmidt-Trucksäss A, Halle M.
Med Sci Sports Exerc. 2009 Sep;41(9): 1826; author reply 1827-8.The 6-min walk test in heart failure: is it a max or sub-maximum exercise test?
Jehn M, Halle M, Schuster T, Hanssen H, Weis M, Koehler F, Schmidt-Trucksäss A.
Eur J Appl Physiol. 2009 Oct;107(3): 317-23. Epub 2009 Jul 18. Physical activity and the metabolic syndrome in elderly German men and women: results from the population-based KORA survey.
Hahn V, Halle M, Schmidt-Trucksäss A, Rathmann W, Meisinger C, Mielck A
Diabetes Care. 2009 Mar;32(3):511-3. Daily walking performance as an independent predictor of advanced heart failure: Prediction of exercise capacity in chronic heart failure.
Jehn M, Schmidt-Trucksäss A, Schuster T, Weis M, Hanssen H, Halle M, Koehler F
Am Heart J. 2009 Feb;157(2):292-8.Left ventricular volumes and mass in marathon runners and their association with cardiovascular risk factors.
Nassenstein K, Breuckmann F, Lehmann N, Schmermund A, Hunold P, Broecker-Preuss M, Sandner TA, Halle M, Mann K, Jöckel KH, Heusch G, Budde T, Erbel R, Barkhausen J, Möhlenkamp S
Int J Cardiovasc Imaging. 2009 Jan;25(1): 71-9. Accelerometer-based quantification of 6-minute walk test performance in patients with chronic heart failure: applicability in telemedicine.
Jehn M, Schmidt-Trucksäess A, Schuster T, Hanssen H, Weis M, Halle M, Koehler F
J Card Fail. 2009 May;15(4):334-40. Epub 2009 Jan 9.

Interval training normalizes cardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy.

Stolen TO, Hoydal MA, Kemi OJ, Catalucci D, Ceci M, Aasum E, Larsen T, Rolim N, Condorelli G, Smith GL, Wisloff U. 
Circ Res 2009;105:527-536.

Comment: This study shows that regular exercise training may have the potential to correct the contractile dysfunction observed in diabetic cardiomyopathy. The exercise training-induced correction occurred due to adaptive behavior of the intracellular structures of the heart muscle cell that control excitation-contraction coupling, such as several protein kinase systems, the transverse tubules, and calcium transport pumps. The study was a collaborative effort of several groups located in Norway, United Kingdom, and Italy.

High-intensity interval training to maximize cardiac benefits of exercise training?
Wisloff U, Ellingsen O, Kemi OJ.
Exerc Sports Sci Rev 2009;37:139-146.

Comment: A commissioned review paper exploring the differential effects of low and high exercise training intensities on improving the pump function of the heart and correcting cardiac pump dysfunction in heart disease, written by past and current members of the EACPR basic and translational research nucleus.

Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity.
Haram PM, Kemi OJ, Lee SJ, Bendheim MO, Al-Share QY, Waldum HL, Gillian LJ, Koch LG, Britton SL, Najjar SM, Wisloff U.
Cardiovasc Res 2009;81:723-732.

Comment: This study adds further evidence to the notion that the beneficial effects of exercise training in cardiovascular dysfunction or disease depend on the intensity with which the exercise is carried out. Here, the scientists showed that exercise training reduces the cardiovascular risk profile in an animal model of the metabolic syndrome; especially with respect to parameters such as exercise capacity and maximal oxygen consumption, endothelial function, blood pressure, and metabolic parameters, that that the risk reduction was greater after high-intensity exercise training. The research was carried out by groups based in Norway, United Kingdom, and United States of America.Circulating CD34+/KDR+ endothelial progenitor cells are reduced in chronic heart failure patients as a function of Type D personality.
Van Craenenbroeck EM, Denollet J, Paelinck BP, Beckers P, Possemiers N, Hoymans VY, Vrints CJ, Conraads VM.
Clin Sci (Lond). 2009;117:165-72.Exercise training reduces circulating adiponectin levels in patients with chronic heart failure.
Van Berendoncks AM, Beckers P, Hoymans VY, Possemiers N, Wuyts FL, Vrints CJ, Conraads VM.
Clin Sci (Lond). 2009 Aug 6. [Epub ahead of print]Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy.
Kemi OJ, Ceci M, Wisloff U, Grimaldi S, Gallo P, Smith GL, Condorelli G, Ellingsen O.
J Cell Physiol. 2008 Feb;214(2):316-21.Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity.
Haram PM, Kemi OJ, Lee SJ, Bendheim MO, Al-Share QY, Waldum HL, Gilligan LJ, Koch LG, Britton SL, Najjar SM, Wisløff U.
Cardiovasc Res. 2008 Dec 18. (Epub ahead of print)Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study.
Tjønna AE, Lee SJ, Rognmo Ø, Stølen TO, Bye A, Haram PM, Loennechen JP, Al-Share QY, Skogvoll E, Slørdahl SA, Kemi OJ, Najjar SM, Wisløff U.
Circulation. 2008 Jul 22;118(4):346-54Myocardial sarcoplasmic reticulum Ca2+ ATPase function is increased by aerobic interval training.
Kemi OJ, Ceci M, Condorelli G, Smith GL, Wisloff U.
Eur J Cardiovasc Prev Rehabil. 2008 Apr;15(2):145-8.Physical activity and mortality in men and women with coronary heart disease: a prospective population-based cohort study in Norway (the HUNT study).
Moholdt T, Wisløff U, Nilsen TI, Slørdahl SA.
Eur J Cardiovasc Prev Rehabil. 2008 Dec;15(6):639-45.Aerobic interval training reduces cardiovascular risk factors more than a multi treatment approach in overweight adolescents.
Tjønna AE, Stølen TO, Bye A, Volden M, Slørdahl SA, Odegård R, Skogvoll E, Wisløff U.
Clin Sci (Lond). 2008 Aug 1. [Epub ahead of print]Methodological approaches to optimize reproducibility and power in clinical studies of flow-mediated dilation.
Donald AE, Halcox JP, Charakida M, Storry C, Wallace SM, Cole TJ, Friberg P, Deanfield JE.
J Am Coll Cardiol. 2008 May 20;51(20):1959-64.Socioeconomic status moderates the association between carotid intima-media thickness and cognition in midlife: evidence from the Whitehall II study.
Singh-Manoux A, Britton A, Kivimaki M, Guéguen A, Halcox J, Marmot M.
Atherosclerosis. 2008 Apr;197(2):541-8. Epub 2007 Sep 14.Potential novel pharmacological therapies for myocardial remodelling.
Landmesser U, Wollert KC, Drexler H.
Cardiovasc Res. 2008 Dec 15. [Epub ahead of print]Accuracy of low-dose computed tomography coronary angiography using prospective electrocardiogram-triggering: first clinical experience.
Herzog BA, Husmann L, Burkhard N, Gaemperli O, Valenta I, Tatsugami F, Wyss CA, Landmesser U, Kaufmann PA.
Eur Heart J. 2008 Dec;29(24):3037-42. Epub 2008 Nov 7.Effect of oral organic nitrates on expression and activity of vascular soluble guanylyl cyclase.
Oppermann M, Dao VT, Suvorava T, Bas M, Kojda G.
Br J Pharmacol. 2008 Oct;155(3):335-42. Epub 2008 Jun 30.Induction of MuRF1 is essential for TNF-alpha-induced loss of muscle function in mice.
Adams V, Mangner N, Gasch A, Krohne C, Gielen S, Hirner S, Thierse HJ, Witt CC, Linke A, Schuler G, Labeit S.
J Mol Biol. 2008 Dec 5;384(1):48-59. Epub 2008 Sep 11.Circulating progenitor cells decrease immediately after marathon race in advanced-age marathon runners.
Adams V, Linke A, Breuckmann F, Leineweber K, Erbs S, Kränkel N, Bröcker-Preuss M, Woitek F, Erbel R, Heusch G, Hambrecht R, Schuler G, Möhlenkamp S.
Eur J Cardiovasc Prev Rehabil. 2008 Oct;15(5):602-7.Increasing physical education in high school students: effects on concentration of circulating endothelial progenitor cells.
Walther C, Adams V, Bothur I, Drechsler K, Fikenzer S, Sonnabend M, Bublitz B, Körner A, Erbs S, Busse M, Schuler G.
Eur J Cardiovasc Prev Rehabil. 2008 Aug;15(4):416-22.Modulation of Murf-1 and MAFbx expression in the myocardium by physical exercise training.
Adams V, Linke A, Gielen S, Erbs S, Hambrecht R, Schuler G.
Eur J Cardiovasc Prev Rehabil. 2008 Jun;15(3):293-9.Local energetic regulation of sarcoplasmic and myosin ATPase is differently impaired in rats with heart failure.
Joubert F, Wilding JR, Fortin D, Domergue-Dupont V, Novotova M, Ventura-Clapier R, Veksler V.
J Physiol. 2008 Nov 1;586(Pt 21):5181-92. Epub 2008 Sep 11.Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha.
Ventura-Clapier R, Garnier A, Veksler V.
Cardiovasc Res. 2008 Jul 15;79(2):208-17.Exercise-induced biphasic increase in circulating NT-proBNP levels in patients with chronic heart failure.
Conraads VM, De Maeyer C, Beckers P, Possemiers N, Martin M, Van Hoof V, Vrints CJ.
Eur J Heart Fail. 2008 Aug;10(8):793-5. Epub 2008 Jul 3.Combined endurance-resistance training vs. endurance training in patients with chronic heart failure: a prospective randomized study.
Beckers PJ, Denollet J, Possemiers NM, Wuyts FL, Vrints CJ, Conraads VM.
Eur Heart J. 2008 Aug;29(15):1858-66. Epub 2008 May 30.
Rate response and cardiac resynchronisation therapy in chronic heart failure: higher cardiac output does not acutely improve exercise performance: a pilot trial.
Van Thielen G, Paelinck BP, Beckers P, Vrints CJ, Conraads VM.Quantification of circulating endothelial progenitor cells: a methodological comparison of six flow cytometric approaches.
Van Craenenbroeck EM, Conraads VM, Van Bockstaele DR, Haine SE, Vermeulen K, Van Tendeloo VF, Vrints CJ, Hoymans VY.
J Immunol Methods. 2008 Mar 20;332(1-2):31-40. Epub 2008 Jan 18.A maximal exercise bout increases the number of circulating CD34+/KDR+ endothelial progenitor cells in healthy subjects. Relation with lipid profile.
Van Craenenbroeck EM, Vrints CJ, Haine SE, Vermeulen K, Goovaerts I, Van Tendeloo VF, Hoymans VY, Conraads VM.
J Appl Physiol. 2008 Apr;104(4):1006-13. Epub 2008 Jan 24.Comparing Type D personality and older age as correlates of tumor necrosis factor-alpha dysregulation in chronic heart failure.
Denollet J, Vrints CJ, Conraads VM.Comparing Type D personality and older age as correlates of tumor necrosis factor-alpha dysregulation in chronic heart failure.
Denollet J, Vrints CJ, Conraads VM.
Brain Behav Immun. 2008 Jul;22(5):736-43. Epub 2008 Feb 20.Heart failure and cachexia: insights offered from molecular biology.
Conraads VM, Hoymans VY, Vrints CJ.
Front Biosci. 2008 Jan 1;13:325-35. Review.Physical activity and the metabolic syndrome in elderly German men and women: Results from the population based KORA survey.
Hahn V, Halle M, Schmidt-Trucksäss A, Rathmann W, Meisinger C, Mielck A.
Diabetes Care. 2008 Dec 15. [Epub ahead of print]Running: the risk of coronary events : Prevalence and prognostic relevance of coronary atherosclerosis in marathon runners.
Möhlenkamp S, Lehmann N, Breuckmann F, Bröcker-Preuss M, Nassenstein K, Halle M, Budde T, Mann K, Barkhausen J, Heusch G, Jöckel KH, Erbel R; Marathon Study Investigators; Heinz Nixdorf Recall Study Investigators.
Eur Heart J. 2008 Aug;29(15):1903-10.Effects of exercise training upon endothelial function in patients with cardiovascular disease.
Linke A, Erbs S, Hambrecht R.
Front Biosci. 2008 Jan 1;13:424-32. Review.

Exercise training restores aerobic capacity and energy transfer systems in heart failure treated with losartan.
Kemi OJ, Hoydal MA, Haram PM, Garnier A, Fortin D, Ventura-Clapier R, Ellingsen O.
Cardiovasc Res 2007;76:91-99

Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholamban.
Kemi OJ, Ellingsen O, Ceci M, Grimaldi S, Smith GL, Condorelli G, Wisloff U.
J Mol Cell Cardiol 2007;43:354-361Prevention of transient endothelial dysfunction in acute exercise: A friendly fire?
Suvorava T, Kojda G.
Thromb Haemost 2007;97:331-3Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study.
Wisloff U, Stoylen A, Loennechen JP, Bruvold M, Rognmo O, Haram PM, Tjonna AE, Helgerud J, Slordahl SA, Lee SJ, Videm V, Bye A, Smith GL, Najjar SM, Ellingsen O, Skjaerpe T.
Circulation 2007;115:3042-4Angiotensin II induces endothelial xanthine oxidase activation: role for endothelial dysfunction in patients with coronary disease.
Landmesser U, Spiekermann S, Preuss C, Sorrentino S, Fischer D, Manes C, Mueller M, Drexler H.
Arterioscler Thromb Vasc Biol. 2007;27:943-8Endogenous endothelin in human coronary vascular function: differential contribution of endothelin receptor types A and B
Halcox JP, Nour KR, Zalos G, Quyyumi AA.
Hypertension 2007;49:1134-41

Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility
Adams V, Linke A, Wisloff U, Doring C, Erbs S, Krankel N, Witt CC, Labeit S, Muller-Werdan U, Schuler G, Hambrecht R.
Cardiovasc Res. 2007;73:120-9

Beneficial effects of endurance training on cardiac and skeletal muscle energy metabolism in heart failure.
Ventura-Clapier R, Mettauer B, Bigard X.
Cardiovasc Res. 2007;73:10-8

The effect of endurance training on exercise capacity following cardiac resynchronization therapy in chronic heart failure patients: a pilot trial.
Conraads V, Vanderheyden M, Paelinck B, Verstreken S, Blankoff I, Miljoen H, De Sutter J, Beckers P.
Eur J Cardiovasc Prev Rehabil. 2007;14:99-106

Combined endurance/resistance training reduces plasma TNF- receptor levels in patients with chronic heart failure and coronary artery disease
Conraads VM, Beckers P, Bosmans J, De Clerck L, Stevens WJ, Vrints CJ and Brutsaert DL.
Eur Heart J 2002; 23(23):1854-1860