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Statin use increases Diabetes Mellitus Risk in postmenopausal women

Comment by Eugenio Greco, EACPR Prevention, Epidemiology and Population Science Section

Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's Health Initiative
A. L. Culver et al.
Arch Intern Med 2012; Advance online publication


Statin use in postmenopausal women is associated with an increased risk of developing Diabetes Mellitus, probably due to a medication class effect: this is the conclusion of Culver et al, in a study published in the Arch Inter Med, on a large cohort of women enrolled in the Women's Health Initiative.

This investigation included 153 840 women without Diabetes Mellitus. Statin use at baseline was associated with an increased risk of Diabetes Mellitus (hazard ratio, 1.71; 95% CI, 1.61-1.83), moreover this association was observed for all types of statin medications.

These data confirm and extend associations demonstrated in other previous studies, giving new insights in the risk-benefit analysis of statin use as primary prevention.