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Join the Multicentre VentHeft Trial!


VentHeft is a multi-centre trial aiming to investigate the additive effects of inspiratory muscle training (IMT) on whole-body endurance training cardiac rehabilitation programs for chronic heart failure patients. Two groups of patients will be studied: in Group I patients will participate in a standard whole-body endurance training program while in Group II a supervised IMT will be added to standard whole-body endurance training programme

Study Protocol: Randomized multi-centre trial
Patient Population:
No of patients: at least 6-8 per group (per centre)
Stable chronic heart failure, NYHA: II-III-IV, LVEF<35%

Group I: Endurance training programme (12 weeks)
Intensity: 60-80% max heart rate (or, better, VO2max if possible) for 45 minutes
Frequency: 3-5/week

Group II: Endurance training programme + IMT (12 weeks)
Intensity: 60-80% max heart rate (or, better, VO2max if possible) for 45 minutes
Frequency: 3-5/week

Device for IMT: computerised system/electronic pressure manometer -TRAINAIR
Intensity: 60% of sustained maximal inspiratory pressure (SPimax) to exhaustion
Frequency: 3-5/week

Measurements (pre and post-training)
Inspiratory muscle strength (Pimax) and inspiratory work capacity (SPimax) (TRAINAIR )
Ergospirometry (peakVO2) and/or 6-min walk test (according to ATS guidelines 2002)
Dyspnea (Borg scale 0-10) at the end of exercise testing
Quality of Life (Minnesota Living with Heart Failure Questionnaire)
Blood sampling

(It is advisable to re-evaluate patients 1 year after the completion of training for mortality and morbidity records)

Do you wish to participate in this interesting multi-centre trial? Contact us!

Principal investigators
Stamatis Adamopoulos email
Miguel Mendes email
Hugo Saner email

Study coordinator
Ioannis Laoutaris email

Coordinating Centre
Onassis Cardiac Surgery Center
356 Sygrou Av.,
176 74, Athens, Greece
Tel: 0030 210 9493000-9493184
Fax: 0030 213 9493186