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Myocardial Function & Cellular Biology of the Heart Meeting 2015

Salvage Pathways in Heart Rejuvenation

Add to calendar30/04/20150:00 03/05/20150:00 Europe/Paris Myocardial Function & Cellular Biology of the Heart Meeting 2015

The joint meeting of Working Groups on Myocardial Function and Cellular Biology of the Heart has became a traditional meeting presenting the cutting-edge of scientific outcomes in dedicated fields.


It offers the opportunity to network and allows scientific exchanges in a friendly and relaxed atmosphere, between early career researchers and outstanding international speakers.

Working Group on Myocardial Function contact@escardio.org true DD/MM/YYYY
Cardiac Cellular Biology
In-person
event
Salvage Pathways in Heart Rejuvenation


Summary

The joint meeting of Working Groups on Myocardial Function and Cellular Biology of the Heart has became a traditional meeting presenting the cutting-edge of scientific outcomes in dedicated fields.


It offers the opportunity to network and allows scientific exchanges in a friendly and relaxed atmosphere, between early career researchers and outstanding international speakers.

With the support of the Heart Failure Association of the ESC,

Astra Zeneca , Sanofi, VisualSonic and the Company of Biologists

 

The joint meeting of Working Groups on Myocardial Function and Cellular Biology of the Heart has became a traditional meeting presenting the cutting-edge of scientific outcomes in dedicated fields.


On parallel, it offers the opportunity to network and allows scientific exchanges in a friendly and relaxed atmosphere.

Early career researchers and outstanding international speakers will share scientific topics in the wonderful setting of the Villa Monastero, bording the Lago di Como in Varenna.

Programme

SALVAGE PATHWAYS IN HEART REJUVENATION”

30 April, 2015
  • 16:25    Welcome
  • 16:30 - 18:30    Pathways of heart rejuvenation and regeneration
    Chairpersons: C. Gabriele Tocchetti, Stephane Heymans, Stefan Frantz
    Molecular control of cardiomyocyte regeneration - Mauro Giacca (25 min + 5 min discussion)

 

Abstract presentations (15 min each + 5 min discussion)
-    GDF11, a novel circulating factor that reverses cardiac hypertrophy – F. Loffredo
-    Involvement of Transient Receptor Potential Channel 6 in the Acute Adaption to increased Cardiac Load and Muscular Dystrophy – P. Rainer
-    Beta3 adrenergic receptors in cardiac myocytes protect from cardiac fibrosis through inhibition of paracrine signalling to fibroblasts: proteomic analysis of the myocyte secretome - N. Hermida
-    NOD2 knock down improves left ventricular function and attenuates pathophysiological key mechanisms in experimental Coxsackievirus B3- induced myocarditis – S. V. Linthout


Panel comments and discussion (10 min)

  • 18.30-19.15  Pre-dinner speech
    Dirk Brutsaert : “REVERIES and CONCOCTIONS
  • 19.30  Dinner
 
1st May, 2015

08.30/10.30 Cardioprotective salvage pathways
Chairpersons: Sandrine Lecour, Peter Ferdinandy

Remote ischemic conditioning and its signal transduction - Gerd Heusch (25 min + 5 min discussion)


Abstract presentations (15 min each + 5 min discussion)
- Soluble factors secreted by regulatory T cells promote cardiomyocyte proliferation during embryonic development and after myocardial infarction – S. Zacchigna
- Inhibition of phosphoinositide 3-kinase γ protects against chemotherapy-induced cardiomyopathy by promoting cardiac autophagy – A. Ghigo
- Viral myocarditis leads to extensive inflammation-induced cardiac metabolic disturbances in mice and man – W. Derks


Panel comments and discussion (10 min)

  • 10.30 - 11.00    Coffee Break

 

  • 11.00/ 13.00 Stem cell and regenerative therapy
    Chairpersons: Joost Sluijter, Felix Engel, Rosalinda Madonna
    Human pluripotent stem cells in cardiovascular disease: the new patient? - Christine Mummery (25 min + 5 min discussion)


Abstract presentations (15 min each + 5 min discussion)
- Mesenchymal and Cardiac Progenitor Cells Suppress T-cell Activity - F. van den Akker
- Embryonic stem cells have a metabolic clock in culture that shifts towards a circadian clock during cardiomyocyte differentiation – P. Dierickx
- The adult myocardium has a robust endogenous cardiomyocyte turnover potential - F. Marino
- Cardiotoxicity by Doxorubicin and Tyrosine Kinase Inhibitors Involves the Pool of Cardiac Progenitors – D. Madeddu


Panel comments and discussion (10 min)

 

  • 13.00 -14.15  Lunch

 

  • 14.15 - 17.45 MODERATED POSTER SESSION 1

 

  • 17.45 - 18.00 Coffee Break

 

  • 18.00-20.00 SIGNALING FROM THE MEMBRANE TO THE NUCLEUS
    Chairpersons: Leon De Windt, Guido Iaccarino, Emilio Hirsch


GRK2 as a signaling hub in cardiovascular disease - Federico Mayor (Madrid) (25 min + 5 min discussion)


Abstract presentations (15 min each + 5 min discussion) –
- PMCA4-mediated signaling in cardiac fibroblasts controls cardiac hypertrophy – R. Abou-Leisa
- Expression of myopalladin mutations in the absence of endogenous myopalladin in mouse results in dilated cardiomyopathy, suggesting that myopalladin mutations have dominant gain-of function effects – MC. Filomena
- Mimetic peptide overcomes dysregulated L-Type Calcium Channel density and recovers myocardial function – D. Catalucci
- GRK2 induces cardiac hypertrophy through the regulation of NFkappaB activity – M. Ciccarelli


Panel comments and discussion (10 min)

  • 20.15 DINNER

 

2nd May, 2015

 

  •  08.30 - 10.30 Mitochondrial salvage pathways
    Chairpersons: Derek J Hausenloy, Sean Davidson
    Ca2+, ROS and mitochondria: same wines, new bottles and different flavors - Fabio Di Lisa (25 min + 5 min discussion)


Abstract presentations (15 min each + 5 min discussion) –
- AKAP121 Deficiency Exacerbates Cardiac Injury in the Ischemic Heart Leading to Heart Failure – F. Cattaneo
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS – V. Pell
- Elevated mitochondrial oxidative stress contributes to decreased heart function in prediabetes – G. Koncsos
- In vivo functional selection identifies ghrelin as an inducer of cardiac protective autophagy and mitophagy – G. Ruozi


Panel comments and discussion (10 min)

 

  • 10.30 - 10.50 COFFEE BREAK

 

  • 10.50 - 13.00 MODERATED POSTER SESSION 2

 

  • 13.00 LUNCH

 

14.00-16.00 Proteostasis and chaperones in salvage pathways
Chairpersons: Denise Hilfiker, Guido Tarone, Jean-Luc Balligand,
Chaperone in the control of titin stretching and diastolic function - Wolfgang Linke. (25 min + 5 min discussion)


Abstract presentations (15 min each + 5 min discussion)
- Functional analyses of lysosomal sialidase Neu1 in inflammatory cells and its potential role in cardiac inflammation after ischemia/reperfusion – I. Gorst
- Sirt1 mediates circadian variation in cardiomyocyte stress tolerance – BC. Du Pre
- In vivo AAV9-mediated Melusin gene delivery prevents left ventricle failure in a mouse model of Emery Dreifuss cardiomyopathy – G. Tarone
- GRK2 subcellular localization in response to radiation stress in cardiac myocytes – A. Franco
Panel comments and discussion (10 min)

FREE AFTERNOON

3rd May, 2015


08.30 - 10.30 Non-coding RNAs as key controller of cardiac remodelling
Chairpersons: Gian Luigi Condorelli, Johan Bauersachs
Long non-coding RNAs and heart failure - Thomas Thum (25 min + 5 min discussion)


Abstract presentations (15 min each + 5 min discussion)
- The microRNA-221/222 family is differentially regulated in cardiac disease and counteracts pressure overload-induced cardiac remodeling in mice – T. Peters
- MiR-216a: a cardiac angiogenic factor – P. da Costa Martins
- Cardiac downregulation of the CalciMiR-139 protects against pressure overload-induced heart failure - T. Peters
- The H19 long non-coding RNA is linked to pathological cardiac hypertrophy - J. Kleeberger


Panel comments and discussion (10 min)


10.30 - 11.00 COFFEE BREAK


11.00 - 11.30 VISUALSONICS


11.30 - 13.00 News and views: PCSK9
Chairpersons: Klaus-Dieter Schluter
Basic aspects of PCSK9. Simon Glerup,
Preclinical pharmacology of PCSK9 inhibition. Uwe Schwahn


13.00/14.00 LUNCH

 

Registration

Registration are now closed

Only active participants (i.e. oral or abstract presenters or chair) will be able to attend the meeting.

NB: The registration fees are covering registration to the meeting, 3 nights of hotel accommodation
(check in on 30 April ; Check out on 3 May 2015) and meals (except Saturday night).
  

Accommodations

Due to limited space scientists are expected to share rooms - for this we need information on gender and age. You may indicate colleagues with whom you prefer to share rooms. However, be informed that we may have to arrange differently.

The organizing committee will coordinate the hotel booking for you and will allocate rooms. You will be notified by email about the location of your hotel in Varenna (30 April-3 May 2015).

Travel and City

Please note that shuttle busses have been arranged from Malpensa Airport to Varenna, accordingly:

Thursday 30 April 2015:
1st Bus Shuttle Malpensa to Varenna
Leaving Malpensa at 11.00 am
Meeting point: at the exit door number 7 of Malpensa terminal 1 arrivals building

2nd Bus Shuttle Malpensa to Varenna
Leaving Malpensa at 14.00 (2.00 pm)
Meeting point: at the exit door number 7 of Malpensa terminal 1 arrivals building

3rd Bus Shuttle Malpensa to Varenna
Leaving Malpensa at 23.15 (11.15 pm)
Meeting point: at the exit door number 7 of Malpensa terminal 1 arrivals building

Sunday 3 May, 2015:
Shuttle Varenna to Malpensa
leaving Varenna  14.15 Meeting point: bus parking after Villa Monastero (on the main road exiting from Varenna direction Lecco - South)

 
May you miss the shuttle, you will have to arrange your travel on your own, as describe below some options:

How to reach Varenna:
By plane: from the airports of Milano Linate and Milano Malpensa, there are special shuttle buses direct to Central Station, from where trains to Sondrio/Tirano - then follow the directions:

Please check the bus shuttle schedules from Milano/Malpensa to Milano Central Station
Please check the train schedules from Milano Central Station to Varenna

By train: from Central Station, take a train to Sondrio/Tirano
     
By car: from Milano take the road to Lecco (SS 36), when arrival in Lecco follow the road along the lake (S. Prov. 72) and then exit at Abbadia Lariana /Mandello /Varenna - Villa Monastero is placed along the road to the country, where there is also a convenient parking lot.

"Fly to Lake-Bus-Shuttle": There is also the possibility to use the "Fly to Lake-Bus-Shuttle" from Milano/Malpensa