Our mission is to become a worldwide reference for education in the field for all professionals involved in the process to dissemintate knowledge & skills of Acute Cardiovascular Care
Our mission is to promote excellence in clinical diagnosis, research, technical development, and education in cardiovascular imaging in Europe.
Our mission: To promote excellence in research, practice, education and policy in cardiovascular health, primary and secondary prevention.
Our goal is to reduce the burden in cardiovascular disease in Europe through percutaneous cardiovascular interventions.
Our Mission is "to improve the quality of life of the population by reducing the impact of cardiac rhythm disturbances and reduce sudden cardiac death"
To improve quality of life and logevity, through better prevention, diagnosis and treatment of heart failure, including the establishment of networks for its management, education and research.
Working Groups goals is to stimulate and disseminate scientific knowledge in different fields of cardiology.
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OUR MISSION: TO REDUCE THE BURDEN OF CARDIOVASCULAR DISEASE
Dr. Willem Dewilde
Assoc. Prof. Marco Valgimigli,
See the press release:Munich, Germany – August 28 2012: Lifelong anticoagulation is necessary for the prevention of stroke in patients with rhythm disturbances and with mechanical valves. Patients who have a coronary stent implanted also need the antiplatelet drugs aspirin and clopidogrel to prevent the rare but lethal complication of stent thrombosis. For patients taking oral anticoagulant drugs (for atrial fibrillation or mechanical valve) who also have to undergo coronary stenting, the optimal antithrombotic treatment is still unknown, even though the use of all three drugs (oral anticoagulants, aspirin and clopidogrel) seems logical for the prevention of stroke and stent thrombosis. However, treatment with all three drugs often causes serious bleeding complications and the frequent need to discontinue the aspirin and clopidogrel...Read more
Presenter: Willem Dewilde | see Discussant report
List of Authors: W. Dewilde1, T. Oirbans2, F. Verheugt3 , J. Kelder2, B. De Smet4, JP. Herrman3, T. Adriaenssens5, M. Vrolix6, A. Heestermans7, M. Vis8, S. Rasoul9, K Sheikjoesoef10, T. Vandendriessche11,C. Van Mieghem12 K.Cornelis13, J.Vos14, B. Brueren15,N. Breet2, J. Ten Berg2(1) Twee Steden Hospital, Department of Cardiology, Tilburg, The Netherlands (2) Sint Antonius Hospital, Centre of platelet function research, Nieuwegein, The Netherlands (3) Onze Lieve Vrouwe Gasthuis, Department of Cardiology, Amsterdam, The Netherlands (4) University Medical Center Groningen, Department of Cardiology, Groningen, The Netherlands (5) Catholic University of Leuven, Department of Cardiology, Leuven, Belgium (6) Hospital Oost-Limburg (ZOL), Department of Cardiology, Genk, Belgium (7) Medical Center Alkmaar, Department of Cardiology, Alkmaar, The Netherlands (8) Academic Medical Center, University of Amsterdam, Department of Cardiology, Amsterdam, The Netherlands (9) Isala Hospital, Department of Cardiology, Zwolle, The Netherlands (10) Maasstad Ziekenhuis, Department of Cardiology, Rotterdam, The Netherlands (11) University Hospital Antwerp, Department of Cardiology , Antwerp, Belgium ( (12) Onze Lieve Vrouw Ziekenhuis, Department of Cardiology, Aalst, Belgium (13) Maria Midderalres, Department of Cardiology, Ghent, Belgium (14) Amphia Hospital, Department of Cardiology , Breda, The Netherlands, (15)Catharina Hospital, Department of Cardiology, Eindhoven, The Netherlands
Background: Oral anticoagulation (OAC) is required in patients with mechanical heart valves and in most patients with atrial fibrillation. When such patients have to undergo percutaneous coronary intervention (PCI), also aspirin and clopidogrel are indicated. However, this triple therapy is known to increase the risk of serious bleeding. Sofar no prospective trial was available in this category of patients.
Methods:In an open-label two country multicenter trial 573 patients on OAC undergoing PCI were randomized to clopidogrel alone (double group, n = 284), or to clopidogrel plus aspirin (triple group, n = 289). The primary outcome consisted of all bleeding events after 1 year classified according to the TIMI bleeding criteria. The secondary endpoint consisted of the combination of death, myocardial infarction, stroke, target vessel revascularisation and stent thrombosis and all individual components of the primary and secondary eindpoints.
Results:Primary outcome occurred in 19.5% in the double group and in 44.9 % in the triple group (p < 0.001,HR=0.3695%CI0.26-0.50) (figure 1). The combined secondary endpoint occurred in 11.3% in the double group and in 17.7% in the triple group (p= 0.025) (figure 2). The rates of myocardial infarction, stroke, target vessel revascularization, or stent thrombosis did not differ significantly, but all-cause mortality was lower in the dual group. (2,5% vs 6.4%, p = 0.027) (figure 3).
Conclusions:In patients on OAC undergoing PCI, clopidogrel alone is associated with significantly less bleeding and mortality at 1 year than the combination of clopidogrel and aspirin without increasing the risk of ischemic stroke or stent thrombosis. We propose that a strategy of clopidogrel plus OAC without aspirin could be applied in this group of high-risk patients.
Discussant: Marco Valgimigli | see Presenter abstract
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Hot Line III: Late Breaking Trials on Arrhythmias and CAD