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Vasa vasorum: involvement in atherosclerosis. From bench to bedside

Chronic Ischaemic Heart Disease (IHD)


Dr Yla-Hertuala outlined that vasa vasorum send vessels into the plaque and suggested that in the plaque angiogenesis takes place; the amount of which probably relates to plaque growing and plaque size. In the plaque VEGF receptors were present and a positive correlation of intima/media ratio and capillary numbers were found.

In the second talk a new technique was introduced which allows observation of vasa vasorum and probably also quantifies them.

Dr Feinstein demonstrated that in a semiquantitative manner it is possible to quatify vasa vasorum using doppler and to correlate these data to the stage of the disease.

Dr Daemen pointed out that new vasa vasorum are very leaky and that rupture therein may contribute to plaque growth. Leakiness is related to the absence of EC junctions and is observed within the plaque hypoxia especially in macrophages.

References


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SessionTitle:

Vasa vasorum: involvement in atherosclerosis. From bench to bedside

Notes to editor


This congress report accompanies a presentation given at the ESC Congress 2009. Written by the author himself/herself, this report does not necessarily reflect the opinion of the European Society of Cardiology.

The content of this article reflects the personal opinion of the author/s and is not necessarily the official position of the European Society of Cardiology.