Our mission is to become a worldwide reference for education in the field for all professionals involved in the process to disseminate knowledge & skills of Acute Cardiovascular Care.
Our mission is to promote excellence in clinical diagnosis, research, technical development, and education in cardiovascular imaging in Europe.
Our mission is to promote excellence in research, practice, education and policy in cardiovascular health, primary and secondary prevention.
Our mission is to reduce the burden of cardiovascular disease in Europe through percutaneous cardiovascular interventions.
Our mission is to improve the quality of life of the population by reducing the impact of cardiac rhythm disturbances and reduce sudden cardiac death.
Our mission is to improve quality of life and longevity, through better prevention, diagnosis and treatment of heart failure, including the establishment of networks for its management, education and research.
The ESC Working Groups' goal is to stimulate and disseminate scientific knowledge in different fields of cardiology.
The ESC Councils' goal is to share knowledge among medical professionals practising in specific cardiology domains.
OUR MISSION: TO REDUCE THE BURDEN OF CARDIOVASCULAR DISEASE
Dr. Zeljko Reiner,
The first presentation in this session was given by D. Ibanez from Madrid, Spain. He showed very elegantly that recombinant Apo AI Milano administration in rabbits resulted in reverse-cholesterol-transport enhancement after 4 days. Even more, it induced a “rescue” from global inflammatory status associated with atherosclerosis. According to the results of this study the Milano form of apo-AI seems to be more efficient in reverse-cholesterol-transport than the apo AI wild type.
The second presentation was given by the same author. In this second study, rabbits were exposed to apo AI Milano, which stabilized the atherosclerotic lesions. However, 6 months later, the acute effect on atherosclerotic plaque volume was still maintained and cholesterol content in plaques from animals receiving apo AI Milano was still significantly lower than in the placebo group. Even the protein expression at the artery wall revealed a lower inflammatory status 6 months after the treatment.
V. Petoumenos from Bonn, Germany presented very interesting results of a study looking into the effects of HDL on endothelial progenitor cells (EPC). The results of the study indicate that HDL has an important effect on number and function of EPC in humans inhibiting EPC apoptosis, enhancing the migratory capacity and improving homing of circulating cells by influencing adhesion possibility due to an up-regulation of CD49d.
J. Johansson from Calgary, Canada showed the first data about a novel small molecule called RVX-208.Oral administration of this substance increases production of apo AI in rodents and some other animals. In healthy volunteers, it was safe at exposure levels shown to increase apo AI production but did not significantly increase HDL-cholesterol.
R Waxman from Washington DC, USA reported on a first-in-man, randomized, placebo-controlled study with autologous delipidated HDL plasma infusions in patients with acute coronary syndrome. Such a treatment was well tolerated, a numeric trend towards reduction in atheroma volume could be seen but, most probably due to a small number of participants, no significant changes in IVUS parameters could be proven.
B. Arsenault from Amsterdam, Netherlands showed results of a prospective case-control study nested in the EPIC-Norfolk cohort on 1035 apparently healthy persons who developed CHD matched to 1920 control subjects. The results indicate that a decreased HDL particle size is associated with an increased CHD risk. However, after controlling for markers of the atherogenic dyslipidemia of the metabolic syndrome such as HDL cholesterol, this association was no longer observed.
High-density lipoprotein and ApoA1-Milano – Full circle from bench to bedside
This congress report accompanies a presentation given at the ESC Congress 2008. Written by the author himself/herself, this report does not necessarily reflect the opinion of the European Society of Cardiology.
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