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Our mission is to reduce the burden of cardiovascular disease in Europe through percutaneous cardiovascular interventions.
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Our mission is to improve quality of life and longevity, through better prevention, diagnosis and treatment of heart failure, including the establishment of networks for its management, education and research.
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OUR MISSION: TO REDUCE THE BURDEN OF CARDIOVASCULAR DISEASE
Presenter report:Tavazzi, Luigi (Italy)
Background. Several epidemiological and experimental studies suggest that n-3 PUFA can exert favorable effects on atherothrombotic cardiovascular disease including arrhythmias. We investigated whether n-3 PUFA could improve morbidity and mortality in a large population of patients with symptomatic heart failure of any cause.Methods. We undertook a randomised, double blind, placebo controlled trial in 357 cardiology sites in Italy. We enrolled 6975 patients with chronic heart failure of New York Heart Association class II-IV, assigned to n-3 PUFA 1 g daily or placebo. Patients were followed up for a median of 3·9 years. Primary end-points were time to death and time to death or admission to hospital for cardiovascular reasons. Analysis was by intention-to-treat population.Findings. 955 (27%) patients died from any cause in the n-3 PUFA group and 1014 (29%) in the placebo group (relative risk reduction 9%, p=0·041). 1981 (57%) patients in the n-3 PUFA group and 2053 (59%) in the placebo group died or were admitted to hospital for cardiovascular reasons (relative risk reduction 8%, p=0·009). In absolute terms, 56 patients needed to be treated for 3.9 years to avoid one death or 44 to avoid one event like death or admission to hospital for cardiovascular reasons. In a per-protocol analysis performed in about 5000 full complier patients, the relative risk of death was reduced by 14% (p 0.004). Safety was excellent. Interpretation.A simple, safe and cheap treatment with n-3 PUFA can provide a moderate beneficial advantage in terms of mortality and admission to hospital for cardiovascular reasons in patients with chronic heart failure in a context of usual care.
This study is registered with Clinical trials.gov., number: NCT00336336.
Discussant: Komajda, Michel (Italy) View the Official Press Release - Effects of n-3 PUFA in Patients With Symptomatic Chronic Heart Failure - Hot Line 1
Hot Line Update I
This congress report accompanies a presentation given at the ESC Congress 2008. Written by the author himself/herself, this report does not necessarily reflect the opinion of the European Society of Cardiology.
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